Nonradioactive sequence-specific oligonucleotide (SSO) probes specific for the HLA-DP beta locus have been used in a simple dot-blot assay to DP beta-type samples amplified by the polymerase chain reaction (pcr) from Caucasoid (n = 24) and Japanese (n = 23) patients with multiple sclerosis (ms) as well as ethnically matched controls. In contrast to previous reports, no DP beta allele was found to be increased in either patient population. However, the results do show a dramatic difference in the allele frequencies between the two control populations, further emphasizing the need for ethnically matched controls in studies of HLA and disease.

译文

对hla-dp β 基因座特异的非放射性序列特异性寡核苷酸 (SSO) 探针已用于简单的斑点印迹分析,通过聚合酶链反应 (pcr) 从高加索人 (n = 24) 扩增的DP β 型样品) 和日本 (n = 23) 多发性硬化症患者 (ms) 以及种族匹配的对照。与以前的报告相反,在两种患者人群中均未发现DP β 等位基因增加。然而,结果确实显示了两个对照人群之间等位基因频率的显着差异,进一步强调了在HLA和疾病研究中需要种族匹配的对照。

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