Immunohistochemical techniques were used to observe the localization of paraquat in the small intestine, liver and kidney, organs that absorb and eliminate chemicals. Paraquat-poisoned rats were killed 3 h, 12 h, 24 h, 3 days, 7 days and 10 days after intravenous administration of paraquat. Three hours after injection, paraquat was localized in hepatocytes and in the kidney in the epithelial cells of the distal tubule. The amount of paraquat in the liver and kidney increased by 24 h after the administration and thereafter decreased with time, suggesting that paraquat is secreted into bile and urine. In the intestine, 3 h after injection, paraquat was localized in the epithelial cells. The same finding was also made in rats with a cannulated bile duct. Therefore, it is likely that paraquat is secreted into the gut lumen from epithelial cells and that paraquat secreted from liver into the duodenum is reabsorbed into the epithelial cells of the intestine.

译文

免疫组织化学技术用于观察百草枯在小肠,肝脏和肾脏,吸收和消除化学物质的器官中的定位。静脉注射百草枯后3 h,12 h,24 h,3天,7天和10天杀死百草枯中毒的大鼠。注射三小时后,百草枯位于肝细胞和远端小管上皮细胞的肾脏中。给药后24小时,肝脏和肾脏中的百草枯量增加,此后随时间减少,这表明百草枯分泌到胆汁和尿液中。在肠中,注射后3小时,百草枯位于上皮细胞中。在具有插管胆管的大鼠中也有相同的发现。因此,百草枯很可能从上皮细胞分泌到肠腔中,而百草枯从肝脏分泌到十二指肠被重新吸收到肠的上皮细胞中。

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