To determine if sleep abnormalities occur in obsessive-compulsive disorder (OCD), 2 nights of sleep electroencephalographic (EEG) recordings were obtained from 13 medication-free outpatients with OCD and 13 age- and sex-matched normal volunteers. Patients were awake more on night 2 than on night 1, whereas control subjects had less time awake on night 1; no other differences between groups were found on sleep latency, sleep time, minutes of movement, sleep efficiency, rapid eye movement (REM) latency or amount of stage 1, 2, 3, or 4 or REM sleep. Within the patient group, total scores on the Yale-Brown Obsessive-Compulsive Scale were negatively correlated with total sleep time (r = -0.51, P = 0.07), sleep efficiency (r = -0.51, P= 0.07), and duration of stage 1 + 2 sleep (r = - 0.49, P = 0.09) but not with REM time (r = - 0.05, P = 0.87) or latency (r = -0.26, P = 0.39). Previous sleep studies in OCD have had divergent results, especially regarding REM latency; our results suggest that many OCD patients have essentially normal sleep EEG findings.

译文

为了确定强迫症 (OCD) 是否发生睡眠异常,从13名无药物的OCD门诊患者和13名年龄和性别匹配的正常志愿者中获得了2晚的睡眠脑电图 (EEG) 记录。患者在第2夜的清醒时间多于第1夜,而对照组在第1夜的清醒时间较少; 两组之间在睡眠潜伏期,睡眠时间,运动分钟,睡眠效率,快速眼动 (REM) 潜伏期或第1、2期的数量上没有其他差异,3、或4或REM睡眠。在患者组中,Yale-Brown强迫量表的总分与总睡眠时间 (r = -0.51,P = 0.07),睡眠效率 (r = -0.51,P = 0.07) 呈负相关。和阶段1 + 2睡眠的持续时间 (r =-0.49,P = 0.09),但不包括REM时间 (r =-0.05,P = 0.87) 或潜伏期 (r = -0.26,P = 0.39)。先前在强迫症中的睡眠研究得出了不同的结果,尤其是在REM潜伏期方面。我们的结果表明,许多强迫症患者的睡眠EEG表现基本正常。

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