The loss of delta9-tetrahydrocannabinol (THCCOOH) from urine specimens stored in polypropylene and polyethylene containers at 4 degrees C and 25 degrees C was examined. All specimens were analyzed by GC-MS after sampling at various times over a one-week period. Data were analyzed by one-way analysis of variance and fitted with a first order kinetic equation. Rapid loss of THCCOOH was seen at 4 degrees C for both polypropylene (14% maximal loss, t(1/2) = 0.53 min) and polyethylene (17% maximal loss, t(1/2) = 5.77 min) bottles. At 25 degrees C, a small loss (< 5%) was observed in polypropylene and no significant loss was seen for urine in polyethylene. All losses stabilized within 1 h, and no further losses were seen over one week. The results indicate that THCCOOH binding may be due to decreased solubility of THCCOOH at lower temperatures and subsequent association of THCCOOH with the more lipophilic plastic. The results also indicate that polypropylene and polyethylene do not bind THCCOOH to such an extent as to compromise the integrity of specimens.

译文

检查了在4 ℃ 和25 ℃ 下储存在聚丙烯和聚乙烯容器中的尿液标本中的delta9-tetrahydrocannabinol (THCCOOH) 损失。在一周内的不同时间采样后,所有标本均通过gc-ms进行分析。通过单因素方差分析分析数据,并用一阶动力学方程拟合。对于聚丙烯 (14% 最大损失,t(1/2) = 0.53分钟) 和聚乙烯 (17% 最大损失,t(1/2) = 5.77分钟),在4 ℃ 下观察到THCCOOH的快速损失。在25 ℃ 下,在聚丙烯中观察到少量损失 (< 5%),在聚乙烯中观察到尿液没有显著损失。所有损失在1小时内稳定下来,一周内没有进一步的损失。结果表明,THCCOOH结合可能是由于THCCOOH在较低温度下的溶解度降低以及随后THCCOOH与亲脂性更强的塑料缔合所致。结果还表明,聚丙烯和聚乙烯不会与THCCOOH结合,从而损害样品的完整性。

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