POCD describes a decline in cognitive function after surgery with a predominance in the elderly patient. Although there is general agreement that POCD is likely to be multifactorial, whether its occurrence is a result of the effects of surgery or general anesthesia remains unclear. This review provides a synopsis of the available clinical and preclinical data and summarizes recent research relevant to the occurrence of POCD and possible pharmacologic algorithms for its prevention and treatment.

译文

POCD描述了老年患者手术后认知功能下降的趋势。尽管人们普遍认为POCD可能是多因素的,但尚不清楚POCD的发生是手术还是全身麻醉的结果。本文概述了现有的临床和临床前数据,并总结了与POCD发生有关的最新研究以及预防和治疗POCD的可能药理算法。

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