Pluronics are triblock copolymers, in which two hydrophilic poly (ethylene oxide) (PEO) blocks are connected via a hydrophobic poly propylene oxide (PPO) block. Because of their low molecular weight and high content of PEO, Pluronics have demonstrated the micellization phenomenon, which is dependent on temperature and/or concentration. With an understanding of micellization phenomenon in more detail, information on the morphology, micelle core radius, aggregation behavior with critical micelle concentration (CMC) and critical micelle temperature (CMT) and so on has been revealed. Based on this acquired information, various studies have been performed for biomedical applications such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. This review discusses the delivery of small molecules and macromolecules using Pluronic-based NPs and their composites.

译文

Pluronics是三嵌段共聚物,其中两个亲水性聚 (环氧乙烷) (PEO) 嵌段通过疏水性聚环氧丙烷 (PPO) 嵌段连接。由于其低分子量和高含量的PEO,Pluronics表现出胶束化现象,这取决于温度和/或浓度。通过对胶束化现象的更详细的了解,揭示了胶束的形态,胶束核心半径,临界胶束浓度 (CMC) 和临界胶束温度 (CMT) 的聚集行为等信息。基于这些获得的信息,已经针对生物医学应用进行了各种研究,例如药物递送系统,组织再生支架和生物表面活性剂。这篇评论讨论了使用基于Pluronic的NPs及其复合材料的小分子和大分子的传递。

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