Polymeric carriers are extensively used in photodynamic therapy (PDT) for increase of efficacy of photosensitizers. Here, we report the influence of nine Pluronic copolymers on phototoxicity of chlorin e6 (Ce6), in particular 5- to 7-fold rise in the phototoxicity caused by hydrophilic Pluronics F127, F108, F68 and F87 and practically no influence on Ce6 of more hydrophobic polymers. The revealed value of 0.2 mg mL(-1) of Pluronic F127 concentration sufficient for half-of-maximal increase of Ce6 photodynamic activity proved to be close to 0.16 mg mL(-1) inherent in well-documented carrier poly(N-vinylpyrrolidone) (PVP). The dissociation constants of Ce6 complexes with Pluronic F127 and PVP that were estimated from UV spectra were 0.252 and 0.036 mg mL(-1) , respectively, indicating higher stability of Ce6 complex with PVP. According to the results of (1) H-NMR studies of Ce6 complexes, the porphyrin interacts not only with hydrophobic regions but also with hydrophilic sides of both polymers.

译文

聚合物载体广泛用于光动力疗法 (PDT) 中,以提高光敏剂的功效。在这里,我们报告了9种Pluronic共聚物对氯蛋白e6 (Ce6) 的光毒性的影响,特别是由亲水性Pluronics F127,F108,F68和F87引起的光毒性增加了5至7倍,实际上对Ce6的影响更多疏水性聚合物。0.2 mg mL(-1) 的Pluronic F127浓度的揭示值足以使Ce6光动力活性的最大增加达到0.16 mg mL(-1),这被证明是在充分证明的载体聚 (N-乙烯基吡咯烷酮) 中固有的 (PVP)。从紫外光谱估计的Ce6与Pluronic F127和PVP配合物的解离常数分别为0.252和0.036 mg mL(-1),表明Ce6与PVP配合物的稳定性更高。根据 (1) 对Ce6配合物的h-nmr研究结果,卟啉不仅与疏水区域相互作用,而且与两种聚合物的亲水侧相互作用。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录