Previous studies in healthy subjects have demonstrated a lack of response of platelets to epinephrine at a rate of 16-40% on an aggregometer. An association between the increased procoagulant factors during pregnancy and venous thromboembolism is known, and it has also been shown that prolactin levels increase platelet aggregation. We evaluated whether platelet functions in pregnant women and also assessed the lack of response to epinephrine during this period. We compared 27 healthy and volunteering pregnant women with 26 similar control subjects. Platelet functions were assessed with an aggregometer and a Platelet Function Analyzer (PFA-100). Less than 40% response to epinephrine on the aggregometer was defined as an impaired epinephrine response. The aggregation response of epinephrine was normal in 25 of the 27 pregnant women, while two of them showed a late-rising response. Eight of the 26 subject control group (30.8%) showed an impaired response to epinephrine. When we compared the 25 pregnant and 18 control subjects with normal aggregation responses, the maximum aggregation responses to ADP and epinephrine, and the Col/Epi and Col/ADP cartridge closure time values were significantly lower in pregnant women. There were no difference between second and third trimesters as regards platelet function parameters. The fact that no impaired response to epinephrine was detected in pregnant women while a 30% rate was observed in non-pregnant women indicates that the platelet malfunction caused by a disorder in the Gi protein and intracellular mechanisms is bypassed during pregnancy thanks to some physiological changes.

译文

先前对健康受试者的研究表明,在聚集计上血小板对肾上腺素的反应缺乏16-40%。已知怀孕期间增加的促凝因子与静脉血栓栓塞之间的关联,并且还表明催乳素水平会增加血小板聚集。我们评估了孕妇的血小板功能,并评估了在此期间对肾上腺素的缺乏反应。我们比较了27名健康和志愿孕妇与26名相似的对照受试者。用聚集计和血小板功能分析仪 (PFA-100) 评估血小板功能。在凝聚仪上对肾上腺素的反应小于40% 被定义为肾上腺素反应受损。在27名孕妇中,有25名肾上腺素的聚集反应正常,而其中两名则显示出较晚的反应。26个受试者对照组中的8个 (30.8%) 显示出对肾上腺素的反应受损。当我们比较25名孕妇和18名正常聚集反应的对照受试者时,孕妇对ADP和肾上腺素的最大聚集反应以及Col/Epi和Col/ADP盒关闭时间值明显较低。在血小板功能参数方面,妊娠中期和妊娠中期之间没有差异。在孕妇中未检测到对肾上腺素的反应受损,而在非孕妇中观察到30% 率的事实表明,由于某些生理变化,在怀孕期间绕过了由Gi蛋白和细胞内机制障碍引起的血小板功能障碍。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录