The incidence of thromboembolism is higher in mitral regurgitation. Mean platelet volume (MPV), which is calculated automatically in the complete blood count tests, indicates platelet production, function and activation. Elevated MPV levels in cardiovascular diseases and some heart valve diseases have been shown before. We aimed to investigate the relationship between MPV and mitral regurgitation, and to evaluate the MPV levels according to the presence of atrial fibrillation or left atrial appendage thrombus in patients with mitral regurgitation for the first time. The study included 57 patients who had undergone transthoracic and transesophageal echocardiography for the classic symptoms and diagnosed with primary (organic) mitral regurgitation. The control group was composed of 46 age, sex and BMI-matched healthy individuals who had undergone transthoracic echocardiography and obtained normal findings. Echocardiographic evaluation was performed according to the recommendations of the American Echocardiography Society. Mean MPV values in patients with mitral regurgitation were significantly higher than the control group (P < 0.001). MPV levels and the thrombus risk were correlated with the severity of the disease. When the patients with mitral regurgitation were classified according to the presence of atrial fibrillation and left atrial appendage thrombus, patients with atrial fibrillation had higher MPV levels compared to patients with normal sinus rhythm (P < 0.001). In addition, highest MPV levels were found in patients with both atrial fibrillation and thrombosis (P < 0.001). In conclusion, measurement of MPV may be considered as a quick and reliable guide in the assessment of mitral regurgitation and thrombus, without any cost or any advanced expensive technology.

译文

二尖瓣反流中血栓栓塞的发生率较高。在整个血液计数测试中自动计算的平均血小板体积 (MPV) 表示血小板的产生,功能和激活。以前已显示心血管疾病和某些心脏瓣膜疾病中的MPV水平升高。本研究旨在探讨MPV与二尖瓣反流的关系,并根据首次发生二尖瓣反流的患者是否存在心房颤动或左心耳血栓来评估MPV水平。该研究包括57例经胸和经食管超声心动图检查经典症状并被诊断为原发性 (器质性) 二尖瓣反流的患者。对照组由46名年龄,性别和BMI相匹配的健康人组成,他们接受了经胸超声心动图检查并获得了正常的发现。根据美国超声心动图学会的建议进行超声心动图评估。二尖瓣反流患者的平均MPV值明显高于对照组 (p  <  0.001)。MPV水平和血栓风险与疾病的严重程度相关。根据是否存在心房颤动和左心耳血栓对二尖瓣关闭不全患者进行分类时,心房颤动患者的MPV水平高于窦性心律正常患者 (p  <  0.001)。此外,房颤和血栓形成患者的MPV水平最高 (p  <  0.001)。总之,MPV的测量可以被认为是评估二尖瓣反流和血栓的快速可靠的指南,而无需任何成本或任何先进的昂贵技术。

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