Beige adipocytes are defined as Ucp1+, multilocular adipocytes within white adipose tissue (WAT) that are capable of thermogenesis, the process of heat generation. In both mouse models and humans, the increase of beige adipocyte population, also called WAT browning, is associated with certain metabolic benefits, such as reduced obesity and increased insulin sensitivity. In this review, we summarize the current knowledge regarding WAT browning, with a special focus on the beige adipocyte plasticity, collectively referring to a bidirectional transition between thermogenic active and latent states in response to environmental changes. We further exploit the utility of a unique beige adipocyte ablation system to interrogate anti-obesity effect of beige adipocytes in vivo.

译文

米色脂肪细胞定义为Ucp1 +,白色脂肪组织 (WAT) 内的多房脂肪细胞,能够产热,产热过程。在小鼠模型和人类中,米色脂肪细胞数量的增加 (也称为WAT褐变) 与某些代谢益处有关,例如肥胖减少和胰岛素敏感性增加。在这篇综述中,我们总结了有关WAT褐变的最新知识,特别关注米色脂肪细胞的可塑性,统称为响应环境变化而在产热活性和潜伏态之间的双向过渡。我们进一步利用独特的米色脂肪细胞消融系统的实用性来询问体内米色脂肪细胞的抗肥胖作用。

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