The placental clearance of selected water-soluble molecules and antipyrine was evaluated using a dual perfusion of human placental lobules in vitro. When graded according to decreasing clearance, the sequence of the molecules was as follows: water = antipyrine greater than urea greater than p-aminohippuric acid greater than inulin greater than dextran 20 greater than dextran 70. A close correlation was obtained between the clearance and the free diffusion coefficient of these molecules. However, no restricted diffusion was observed in the molecular range studied. These results suggest an equivalent pore size larger than 90 A for the human placental membrane in vitro.

译文

使用体外人胎盘小叶的双重灌注评估了所选水溶性分子和安替比林的胎盘清除率。当根据清除率的降低进行分级时,分子的顺序如下: 水 = 安替比林大于尿素大于对氨基马尿酸大于菊粉大于葡聚糖20大于葡聚糖70。在这些分子的间隙和自由扩散系数之间获得了密切的相关性。然而,在所研究的分子范围内未观察到限制扩散。这些结果表明,体外人胎盘膜的等效孔径大于90 A。

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