Electroconvulsive therapy (ECT) is effective for patients with antidepressant medication-resistant depression. However, the mechanisms of ECT's effectiveness for treating depression are not fully understood. We therefore investigated ECT's effects on blood levels of brain-derived neurotrophic factor (BDNF), catecholamine metabolites, and nitric oxide (NO) in 18 treatment-refractory depressed patients. Serum BDNF levels increased significantly following ECT in responders to ECT (before ECT: 8.0+/-9.7 ng/mL; five weeks after start of ECT: 15.1+/-11.1 ng/mL), whereas BDNF levels in non-responders were unchanged (before ECT: 11.5+/-11.0 ng/mL; five weeks after start of ECT: 9.4+/-7.5 ng/mL). Furthermore, the plasma HVA levels, but not MHPG levels, were significantly reduced after ECT (before ECT: 8.5+/-1.9 ng/mL; five weeks after start of ECT: 5.8+/-2.2 ng/mL). This latter finding occurred in parallel with the improvement of depressive symptoms in all patients. These results suggest that the mechanisms underlying ECT's effect on refractory depression may be related to dopaminergic neurons and BDNF.

译文

电惊厥疗法 (ECT) 对抗抑郁药物耐药抑郁症患者有效。然而,ECT治疗抑郁症的有效性机制尚不完全清楚。因此,我们研究了ECT对18例难治性抑郁症患者的脑源性神经营养因子 (BDNF),儿茶酚胺代谢物和一氧化氮 (NO) 的血液水平的影响。ECT应答者的血清BDNF水平在ECT后显着升高 (ECT之前: 8.0/-9.7 ng/mL; ECT开始后五周: 15.1/-11.1 ng/mL),而非应答者的BDNF水平没有变化 (ECT之前: 11.5 +/-11.0 ng/mL; 开始ECT后五周: 9.4 +/-7.5 ng/mL。此外,在ECT之后 (ECT之前: 8.5 +/-1.9 ng/mL; ECT开始后五周: 5.8 +/-2.2 ng/mL),血浆HVA水平而非MHPG水平显著降低。后一种发现与所有患者的抑郁症状改善同时发生。这些结果表明,ECT对难治性抑郁症的作用机制可能与多巴胺能神经元和BDNF有关。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录