Vasculogenic mimicry (VM) is regarded as a process where very aggressive cancer cells generate vascular-like patterns without the presence of endothelial cells. It is considered as the main mark of malignant cancer and has pivotal role in cancer metastasis and progression in various types of cancers. On the other hand, resistance to the antiangiogenesis therapies leads to the cancer recurrence. Therefore, development of novel chemotherapies and their combinations is urgently needed for abolition of VM structures and also for better tumor therapy. Hence, identifying compounds that target VM structures might be superior therapeutic factors for cancers treatment and controlling the recurrence and metastasis. In recent times, naturally occurring compounds, especially phytochemicals have obtained great attention due to their safe properties. Phytochemicals are also capable of targeting VM structure and also their main signaling pathways. Consequently, in this review article, we illustrated key signaling pathways in VM, and the phytochemicals that affect these structures including curcumin, genistein, lycorine, luteolin, columbamine, triptolide, Paris polyphylla, dehydroeffusol, jatrorrhizine hydrochloride, grape seed proanthocyanidins, resveratrol, isoxanthohumol, dehydrocurvularine, galiellalactone, oxacyclododecindione, brucine, honokiol, ginsenoside Rg3, and norcantharidin. The recognition of these phytochemicals and their safety profile may lead to new therapeutic agents' development for VM elimination in different types of tumors.

译文

血管生成拟态 (VM) 被认为是一种过程,其中非常具有侵略性的癌细胞在没有内皮细胞存在的情况下产生血管样模式。它被认为是恶性肿瘤的主要标志,在各种类型的癌症的转移和进展中起着举足轻重的作用。另一方面,对抗血管生成疗法的抵抗力导致癌症复发。因此,迫切需要开发新型化学疗法及其组合,以消除VM结构并更好地进行肿瘤治疗。因此,确定靶向VM结构的化合物可能是癌症治疗和控制复发和转移的更好治疗因素。近年来,天然存在的化合物,尤其是植物化学物质由于其安全特性而引起了极大的关注。植物化学物质也能够靶向VM结构及其主要信号通路。因此,在这篇综述文章中,我们说明了VM中的关键信号通路,以及影响这些结构的植物化学物质,包括姜黄素,染料木黄酮,石蒜素,木犀草素,哥伦巴胺,雷公藤甲素,巴黎多叶,脱氢排香酚,盐酸苦果碱,葡萄籽原花青素,白藜芦醇和好醇、人参皂苷Rg3和去甲斑鸠苷。对这些植物化学物质及其安全性的认识可能会导致在不同类型的肿瘤中消除VM的新治疗剂的发展。

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