Articular cartilage serves as a load-bearing elastic material that is responsible for the frictionless movement of the surfaces of articulating joints. Its ability to undergo reversible deformation depends on its structural organization, including the specific arrangement of the matrix macromolecules and the chondrocytes. Interactions between the matrix and chondrocytes are responsible for the biological and mechanical properties of articular cartilage and enable it to respond by effecting a balance between anabolism and catabolism as well as continual internal remodeling. Age-related changes in the function of chondrocytes may contribute to the initiation and progression of osteoarthritis.

译文

关节软骨是一种承重的弹性材料,负责关节关节表面的无摩擦运动。它进行可逆变形的能力取决于其结构组织,包括基质大分子和软骨细胞的特定排列。基质和软骨细胞之间的相互作用负责关节软骨的生物学和机械特性,并通过影响合成代谢和分解代谢之间的平衡以及持续的内部重塑来使其做出反应。软骨细胞功能的年龄相关变化可能有助于骨关节炎的发生和发展。

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