Cannabis sativa has been known, used, and misused by mankind for centuries, and yet only over the last two decades has research stemming from the chemical constituents specific to this plant, the cannabinoids, started to provide fundamental insights into animal physiology and pathology, resulting in the development of new therapeutics. The discovery of the endocannabinoid system, and its targeting with two new pharmaceutical preparations now on the market in several countries, represent the most recent example of how studies on medicinal plants and on the mechanism of their biological effects can reveal, through a chain of breakthroughs, new systems of endogenous signals and physiological phenomena that can become the source of novel strategies for unmet therapeutic challenges.

译文

大麻已经被人类认识,使用和滥用了几个世纪,但仅在过去的二十年中,来自该植物特有的化学成分大麻素的研究开始提供对动物生理学和病理学的基本见解,导致新疗法的发展。内源性大麻素系统的发现及其以目前在几个国家市场上的两种新药物制剂为目标,代表了对药用植物及其生物效应机制的研究如何通过一系列突破揭示的最新例子,内源性信号和生理现象的新系统,可以成为应对未解决的治疗挑战的新策略的来源。

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