Cellular function requires coordination between different organelles and metabolic cues. Mitochondria and lysosomes are essential for cellular metabolism as major contributors of chemical energy and building blocks. It is therefore pivotal for cellular function to coordinate the metabolic roles of mitochondria and lysosomes. However, these organelles do more than metabolism, given their function as fundamental signaling platforms in the cell that regulate many key processes such as autophagy, proliferation, and cell death. Mechanisms of crosstalk between mitochondria and lysosomes are discussed, both under physiological conditions and in diseases that affect these organelles.

译文

细胞功能需要不同细胞器和代谢线索之间的协调。线粒体和溶酶体对于细胞代谢至关重要,是化学能和组成部分的主要贡献者。因此,协调线粒体和溶酶体的代谢作用对于细胞功能至关重要。然而,这些细胞器不仅仅是代谢,因为它们作为细胞中的基本信号平台,调节许多关键过程,如自噬、增殖和细胞死亡。讨论了在生理条件下和影响这些细胞器的疾病中线粒体和溶酶体之间的串扰机制。

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