A study of three fluorescent anthroyl probes has been carried out using pure and mixed monomolecular films with dipalmitoylphosphatidylcholine. In addition, fluorescence depolarization and differential scanning calorimetry data were obtained from dipalmitoylphosphatidylcholine vesicles with incorporated anthroyl probes. The three probes used were 2-(9-anthroyl)palmitic acid. 12-(9-anthroyl)stearic acid, and 16-(9-anthroyl)palmitic acid. The latter probe was synthesized for these studies. In monolayers the probes shifted the onset of the liquid-condensed/liquid-expanded monolayer phase transition with the extent of the shift decreasing in the order2-(9-anthroyl)palmitic acid greater than 12-(9-anthroyl)stearic acid greater than 16-(9-anthroyl)stearic acid. A corresponding decrease in the gel-liquid crystalline bilayer transition temperature (Tc) showed the same order of perturbation in both the fluorescence depolarization and differential scanning calorimetry data. Locating the anthroyl entity in the center of the bilayer would appear to provide a minimum perturbation.

译文

已使用纯的和混合的单分子膜与二棕榈酰磷脂酰胆碱进行了对三种荧光拟人基探针的研究。此外,荧光去极化和差示扫描量热法数据是从结合了人角基探针的二棕榈酰磷脂酰胆碱囊泡获得的。使用的三种探针是2-(9-甘草酸) 棕榈酸。12-(9-甘草酸) 硬脂酸,和16-(9-人甘草酸) 棕榈酸。后一种探针是为这些研究合成的。在单层中,探针改变了液体冷凝/液体膨胀单层相变的开始,而这种转变的程度以2-(9-人甘草酸) 大于12-(9-人甘草酸) 的顺序减小硬脂酸大于16-(9-拟人酰) 硬脂酸。凝胶-液晶双分子层转变温度 (Tc) 的相应降低在荧光去极化和差示扫描量热法数据中显示出相同的扰动顺序。将拟人酰实体定位在双分子层的中心似乎提供了最小的摄动。

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