Albino and pigmented (black-hooded) rats of the Sprague-Dawley and Long Evans strains, respectively, were compared in terms of their susceptibility to retinal damage by ultraviolet-A light. Anesthetized animals were exposed to ultraviolet-A light (lambda max = 360 nm) for 4 hr and retinal damage was assessed 1 week later by electroretinographic analysis and measurement of outer nuclear layer thickness. Albino and pigmented animals showed approximately the same severity of ultraviolet-A retinal damage as a function of exposure irradiance. Furthermore, both pigmentation strains showed swelling and vesiculation of rod inner segment mitochondria as an early manifestation of damage. An abbreviated study on a congenic rat strain (F344-c/+) of albino and pigmented littermates again demonstrated an equal susceptibility to ultraviolet-A phototoxicity for both pigmentation phenotypes. These findings provide evidence that melanin is not the mediator of short-wavelength phototoxicity to the retina, since damage readily occurred in albino animals completely lacking this chromophore.

译文

分别比较了Sprague-Dawley和Long Evans品系的白化病大鼠和有色 (黑帽) 大鼠对紫外线A光对视网膜损伤的敏感性。将麻醉的动物暴露于紫外线A光 (最大 λ = 360 nm) 4小时,并在1周后通过视网膜电图分析和测量外核层厚度评估视网膜损伤。白化病和有色动物表现出与暴露辐照度有关的紫外线-视网膜损伤的严重程度大致相同。此外,两种色素沉着菌株均显示杆状内段线粒体肿胀和囊泡,这是损伤的早期表现。对白化病和有色同窝的同系大鼠品系 (F344-c/) 的简短研究再次表明,两种色素沉着表型对紫外线-a光毒性的敏感性相同。这些发现提供了证据,表明黑色素不是对视网膜短波长光毒性的介体,因为完全缺乏这种发色团的白化病动物很容易发生损害。

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