Methoxsalen (8-methoxypsoralen) was used as the photoxic substance in the study of the properties of various vehicles in photoepicutaneous testing. Macrogols as such were relatively poor bases, and positive reactions were seen only occasionally at a concentration of 0.05% methoxsalen. Increasing amounts of water in macrogols brought forth more numerous and stronger reactions. The photoxicity also increased when ethanol was added. The reactions were, however, weaker than to those with aqueous bases. Wool fat and glycerol as vehicles usually reacted in the same way as polyethylene glycols when water was added. An explanation of the mechanism of the changes in the properties of vehicles due to the addition of water/ethanol requires further investigation.

译文

甲氧沙林 (8-甲氧基补骨脂素) 被用作光氧化物质,用于研究光表皮测试中各种媒介物的特性。像这样的大分子是相对较差的碱基,并且仅在0.05% 甲氧沙林浓度下偶尔看到阳性反应。大分子中的水量增加会引起更多更强烈的反应。加入乙醇后,光x度也会增加。但是,该反应比具有水性碱的反应弱。当加入水时,作为载体的羊毛脂肪和甘油通常以与聚乙二醇相同的方式反应。对由于添加水/乙醇而导致车辆性能变化的机理的解释需要进一步研究。

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