A series of substituted xanthonyloxyacetic acids (5 and 6), 1,2-dihydrofuro[2,3-c]xanthone-2-carboxylic acids (7) and 2,3-dihydrofuro[3,2-b]xanthone-2-carboxylic acids (8) were synthesized and tested for diuretic and uricosuric activities in rats. Most of the xanthon-3-yloxyacetic acids (5) and 7 showed potent diuretic activities, while 8 had lower activities. Uricosuric activities were found in 5c, 5f, 5k, 5m, 5o, 5p, 5r, 7m, 7p and 8q.
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【Studies on uricosuric diuretics. I. Syntheses and activities of xanthonyloxyacetic acids and dihydrofuroxanthone-2-carboxylic acids.].
【尿尿利尿剂的研究。I.黄嘌呤氧乙酸和dihydrofuroxanthone-2-carboxylic的合成和活性。】
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DOI：10.1248/cpb.38.1266文章类型：杂志文章
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一系列取代的黄环氧乙酸 (5和6)，1,2-二氢呋喃 [2,3-c]xanthone-2-carboxylic (7) 和2,3-二氢呋喃 [3，合成了2-b]xanthone-2-carboxylic酸 (8) 并测试了大鼠的利尿和尿尿活性。大多数xanthon-3-yloxyacetic酸 (5) 和7表现出强效的利尿活性，而8表现出较低的活性。在5c，5f，5k，5m，5o，5p中发现尿尿活性。5r、7m、7p和8q。
