The rhizomes of Astilbe rivularis, commonly known as 'Thulo Okhati' are widely used in Nepal as tonic for uterine and menstrual disorders. In our preliminary study, the 70% MeOH extract of the rhizomes showed potent antioxidant activity. Hence, present study was aimed for the isolation of potent antioxidant constituents. Bergenin (1), 11-O-galloylbergenin (2), (+)-catechin (3), (-)-catechin (4), (-)-afzelechin (5), (-)-epiafzelechin (6) and 2-(β-D-glucopyranosyloxy)-4-hydroxylbenzenacetonitrile (7) were isolated from the rhizomes. Structures of these compounds were elucidated on the basis of spectroscopic methods. All these isolated compounds were evaluated for their in vitro antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. 11-O-Galloylbergenin (2), (+)-catechin (3), (-)-catechin (4), (-)-afzelechin (5) and (-)-epiafzelechin (6) showed potent antioxidant activity.

译文

落新鸟的根茎,通常被称为 “thulo okhathis”,在尼泊尔被广泛用作子宫和月经失调的补品。在我们的初步研究中,根茎的70% MeOH提取物显示出强大的抗氧化活性。因此,本研究旨在隔离有效的抗氧化剂成分。Bergenin (1),11-O-没食子酰Bergenin (2),(+)-儿茶素 (3),(-)-儿茶素 (4),(-)-afzelechin (5),从根茎中分离出 (-)-epiafzelechin (6) 和2-(β-D-吡喃葡萄糖氧基)-4-羟基苯乙腈 (7)。根据光谱方法阐明了这些化合物的结构。通过1,1-二苯基-2-吡啶肼基 (DPPH) 自由基清除试验评估了所有这些分离的化合物的体外抗氧化活性。11-O-没食子酰bergenin (2),()-儿茶素 (3),(-)-儿茶素 (4),(-)-afzelechin (5) 和 (-)-epiafzelechin (6) 显示出强大的抗氧化活性。

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