Thioredoxin-1 (TRX) is a small redox-active protein with antioxidative effects and redox-regulating functions. Cigarette smoking is a major etiological factor in the pathogenesis of a variety of diseases and recruits systemic immune and inflammatory responses. This report demonstrates that TRX attenuates the systemic inflammatory responses induced by cigarette smoking. The mRNA expressions of tumor necrosis factor alpha (TNF-alpha) and macrophage migration inhibitory factor (MIF) were suppressed in the spleen of TRX overexpressing transgenic mice (TRX-tg) exposed to cigarette smoking, compared with control C57BL/6 mice. In addition, protein carbonylation, a marker of cellular protein oxidation, was enhanced by cigarette smoking in the tissues of heart and liver in control mice more than in TRX-tg mice. These findings suggest that TRX may suppress the systemic inflammatory responses against cigarette smoking.

译文

Thioredoxin-1 (TRX) 是一种小的氧化还原活性蛋白,具有抗氧化作用和氧化还原调节功能。吸烟是多种疾病发病的主要病因,并引发全身免疫和炎症反应。该报告表明TRX可以减轻吸烟引起的全身炎症反应。与对照组C57BL/6小鼠相比,吸烟时TRX过表达转基因小鼠 (TRX-tg) 脾脏中肿瘤坏死因子 α (TNF-α) 和巨噬细胞移动抑制因子 (MIF) 的mRNA表达受到抑制。此外,对照小鼠的心脏和肝脏组织中的吸烟比TRX-tg小鼠更多地增强了蛋白质羰基化,这是细胞蛋白质氧化的标志。这些发现表明,TRX可能会抑制针对吸烟的全身炎症反应。

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