Tuberculosis control is hampered by the widespread increase in multidrug resistance. Rapid drug susceptibility testing would greatly aid in the adequate treatment of the disease. This study evaluates the usefulness of the colorimetric method using Alamar Blue for the rapid detection of resistance to rifampicin and isoniazid in 63 clinical isolates of Mycobacterium tuberculosis in Peru. Results obtained by receiver operating characteristic curve analysis and measures of gain in certainty showed greater diagnostic accuracy than with the gold standard, the proportion method on Löwenstein-Jensen medium.

译文

多药耐药性的广泛增加阻碍了结核病的控制。快速的药物敏感性测试将极大地帮助该疾病的适当治疗。这项研究评估了使用Alamar Blue的比色法在秘鲁63种结核分枝杆菌临床分离株中快速检测对利福平和异烟肼的耐药性的有用性。通过接收器工作特性曲线分析和确定性增益测量获得的结果显示出比金标准 (Löwenstein-Jensen培养基上的比例方法) 更高的诊断准确性。

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