We investigated the prevalence and molecular epidemiology of human T cell lymphotropic virus type 1 in Peruvian HIV-1-positive subjects, and found a 10.1% prevalence in a consecutive series of 318 HIV-1-positive patients living in Lima. Phylogenetic analysis of the long terminal repeat of 10 patient isolates showed that all of them belonged to the HTLV-1aA (Transcontinental) subgroup. Although the majority of the Peruvian sequences included in the analysis formed a clade with other Latin American sequences, the isolates of three patients clustered significantly with South African strains. These data show a high prevalence of HTLV-1 infection in HIV-1-positive subjects living in Lima and confirm the presence in Latin America of HTLV-1 strains probably arising from South Africa.

译文

我们调查了秘鲁HIV-1-positive受试者中1型人类T细胞淋巴细胞病毒的患病率和分子流行病学,并在连续318名HIV-1-positive患者中发现了10.1% 的患病率。对10个患者分离株的长末端重复序列的系统发育分析表明,它们全部属于HTLV-1aA (跨大陆) 亚组。尽管分析中包含的大多数秘鲁序列与其他拉丁美洲序列形成了进化枝,但三名患者的分离株与南非菌株显着聚集。这些数据表明,生活在利马的HIV-1-positive受试者中HTLV-1感染的患病率很高,并证实了拉丁美洲可能来自南非的HTLV-1菌株的存在。

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