To assess the epidemiology of hepatitis B virus (HBV) infection among men who have sex with men (MSM) in Peru, we evaluated the prevalence and associated risk factors for HBV serologic markers among participants of a HIV sentinel surveillance conducted in 2002-2003. The standardized prevalences for total antibodies to hepatitis B core antigen (anti-HBc) and hepatitis B surface antigen (HBsAg) were 20.2% and 2.8%, respectively. Individuals with human immunodeficiency virus (HIV-1) infection had significantly higher anti-HBc (44.3% versus 19.3%) and HBsAg (9.5% versus 2.3%) prevalences than uninfected men. Increasing age (adjusted odds ratio [AOR] = 1.06), versatile sexual role (AOR = 1.59), sex in exchange for money/gifts (AOR = 1.58), syphilis (AOR = 1.74), HIV-1 infection (AOR = 1.64), and herpes simplex virus type 2 (HSV-2, AOR = 2.77) infection were independently associated with anti-HBc positivity, whereas only HIV-1 infection (AOR = 3.51) and generalized lymph node enlargement (AOR = 3.72) were associated with HBsAg positivity. Pre-existing HBV infection is very common among Peruvian MSM and was correlated with sexual risk factors. MSM in Peru constitute a target population for further HBV preventive and treatment interventions.

译文

为了评估在秘鲁与男性 (MSM) 发生性关系的男性中乙型肝炎病毒 (HBV) 感染流行病学,我们评估了2002-2003年进行的HIV前哨监测参与者中HBV血清学标志物的患病率和相关危险因素。针对乙型肝炎核心抗原 (抗-HBc) 和乙型肝炎表面抗原 (HBsAg) 的总抗体的标准化患病率分别为20.2% 和2.8%。与未感染的男性相比,人类免疫缺陷病毒 (HIV-1) 感染的个体具有显着更高的抗HBc (44.3% 对19.3%) 和HBsAg (9.5% 对2.3%) 患病率。年龄增长 (调整后的优势比 [AOR] = 1.06),多才多艺的性角色 (AOR = 1.59),以换取金钱/礼物的性行为 (AOR = 1.58),梅毒 (AOR = 1.74),HIV-1感染 (AOR = 1.64) 和2型单纯疱疹病毒 (HSV-2,AOR = 2.77) 感染与抗HBc阳性独立相关,而只有HIV-1感染 (AOR = 3.51) 和广泛性淋巴结肿大 (AOR = 3.72) 与HBsAg阳性相关。先前存在的HBV感染在秘鲁MSM中非常常见,并且与性危险因素相关。秘鲁的MSM构成了进一步的HBV预防和治疗干预的目标人群。

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