A morphologic study of the impact of aging on neuron marker expression was performed in different segments of the rat spinal cord. Spinal cord specimens from young (5 months), middle-aged (12 months) and senile (32 months) female rats were assessed. We found a complete loss of neuron-specific nuclear protein (NeuN) immunoreactivity in cervical, thoracic and lumbar segments of the senile animals whereas neuron-specific enolase (NSE) immunoreactivity was comparable in young and senile rats. These findings in otherwise morphologically well preserved spinal cord neurons are of interest and reveal that NeuN may not be a reliable marker to identify neurons in the spinal cord of aging rats.

译文

在大鼠脊髓的不同节段中进行了衰老对神经元标志物表达影响的形态学研究。评估年轻 (5个月),中年 (12个月) 和老年 (32个月) 雌性大鼠的脊髓标本。我们发现老年动物的颈,胸和腰段神经元特异性核蛋白 (NeuN) 免疫反应性完全丧失,而年轻和老年大鼠的神经元特异性烯醇化酶 (NSE) 免疫反应性相当。在其他形态学上保存良好的脊髓神经元中的这些发现令人感兴趣,并且表明NeuN可能不是鉴定衰老大鼠脊髓神经元的可靠标记。

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