This study investigated the effect of co-administration of the selective 5-HT1A receptor antagonist WAY 100,635 and selective 5-HT(1B/1D) receptor antagonist GR 127,935 with a subactive dose of citalopram [selective serotonin (5-HT) reuptake inhibitor (SSRI)] on the expression of conditioned freezing, an index of fear. In the present study, acute administration of citalopram (s.c.) reduced freezing significantly at high doses (10, 30 and 100 mg/kg), while showing no significant effect at low doses (1 and 3 mg/kg). Co-administration of WAY 100,635 (0.15 mg/kg) with citalopram (3 mg/kg) reduced freezing markedly and significantly, as compared with either drug alone. However, the addition of GR 127,935 (4 mg/kg) did not potentiate the effects of citalopram (3 mg/kg) on freezing and did not enhance the effect of WAY 100,635 (0.15 mg/kg) with citalopram (3 mg/kg). Co-administration of WAY 100,635 (0.15 mg/kg) or GR 127,935 (4 mg/kg) gave no effect on high-dose citalopram (30 mg/kg)-induced inhibition of freezing behavior. These results suggest that co-administration of WAY 100,635 (0.15 mg/kg) strengthens the anxiolytic effect of citalopram (3 mg/kg) by facilitating central 5-HT neurotransmission. Since GR 127,935 (4 mg/kg) failed to accelerate the inhibition of freezing induced by citalopram (3 mg/kg) with WAY 100,635 (0.15 mg/kg) or citalopram (3 mg/kg) alone, it is suggested that blocking 5-HT1A receptors is more effective in facilitating the anxiolytic effect of citalopram than blocking 5-HT1B/1D receptors.

译文

本研究调查了选择性5-HT1A受体拮抗剂WAY 100,635和选择性5-HT(1B/1D) 受体拮抗剂GR 127,935与亚活性剂量西酞普兰 [选择性5-羟色胺 (5-HT) 再摄取抑制剂 (SSRI)] 共同给药对条件冷冻 (恐惧指数) 表达的影响。在本研究中,在高剂量 (10、30和100 mg/kg) 下,西酞普兰 (s.c.) 的急性给药显著降低了冷冻,而在低剂量 (1和3 mg/kg) 下没有显著效果。与单独使用任何一种药物相比,路100,635 (0.15 mg/kg) 与西酞普兰 (3 mg/kg) 的共同给药显着降低了冷冻。然而,添加GR 127,935 (4 mg/kg) 不能增强西酞普兰 (3 mg/kg) 对冷冻的作用,也不能增强西酞普兰 (3 mg/kg) 对WAY 100,635 (0.15 mg/kg) 的作用。100,635 (0.15 mg/kg) 或GR 127,935 (4 mg/kg) 的共同给药对大剂量西酞普兰 (30 mg/kg) 诱导的冷冻行为抑制没有影响。这些结果表明,联合给予WAY 100,635 (0.15 mg/kg) 通过促进中枢5-HT神经传递来增强西酞普兰 (3 mg/kg) 的抗焦虑作用。由于GR 127,935 (4 mg/kg) 未能加速西酞普兰 (3 mg/kg) 与WAY 100,635 (0.15 mg/kg) 或西酞普兰 (3 mg/kg) 单独诱导的冷冻抑制,建议阻断5-HT1A受体比阻断5-HT1B/1D受体更有效地促进西酞普兰的抗焦虑作用。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录