To our knowledge, the relationship between gallbladder volume and cystic duct function has not been studied. We hypothesized that changes in gallbladder volume would influence cystic duct resistance. The effect of gallbladder volume changes on cystic duct resistance to both prograde (emptying) and retrograde (filling) steady-state flow was tested in 12 dogs under basal cholecystokinin-stimulated conditions utilizing a multiport catheter with a highly compliant balloon placed within the gallbladder fundus. Gallbladder volume was regulated by varying balloon volume from empty to just beyond physiologic distention. Cystic duct resistance was not affected by balloon volume under basal or stimulated conditions or by the direction of perfusate flow. This study demonstrated no relationship between gallbladder volume and cystic duct resistance and did not demonstrate a cystic duct sphincter mechanism at physiologic gallbladder volumes.

译文

据我们所知,胆囊体积与胆囊管功能之间的关系尚未得到研究。我们假设胆囊体积的变化会影响胆囊管阻力。在12只狗中,在基础胆囊收缩素刺激的条件下,使用多端口导管在胆囊内放置了高度顺应性球囊,测试了胆囊体积变化对胆囊管对顺行 (排空) 和逆行 (充盈) 稳态血流的阻力的影响。胆囊底。胆囊体积通过改变从空的球囊体积到超出生理扩张来调节。在基础或刺激条件下,囊管阻力不受球囊体积或灌注液流动方向的影响。这项研究表明胆囊体积与胆囊管阻力之间没有关系,也没有显示生理性胆囊体积的胆囊管括约肌机制。

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