Epidemiological studies indicate that diets rich in fruits and vegetables (F&V) are protective against CVD. Puréed F&V products retain many beneficial components, including flavonoids, carotenoids, vitamin C and dietary fibres. The present study aimed to establish the physiological effects of acute ingestion of a F&V purée-based drink (FVPD) on vasodilation, antioxidant status, phytochemical bioavailability and other CVD risk factors. A total of twenty-four subjects, aged 30-70 years, completed the randomised, single-blind, controlled, crossover test meal study. Subjects consumed 400 ml of the FVPD, or a fruit-flavoured sugar-matched control, after following a low-flavonoid diet for 5 d. Blood and urine samples were collected throughout the study day, and vascular reactivity was assessed at 90 min intervals using laser Doppler iontophoresis. The FVPD significantly increased plasma vitamin C (P= 0·002) and total nitrate/nitrite (P= 0·001) concentrations. There was a near significant time by treatment effect on ex vivo LDL oxidation (P= 0·068), with a longer lag phase after consuming the FVPD. During the 6 h after juice consumption, the antioxidant capacity of plasma increased significantly (P= 0·003) and there was a simultaneous increase in plasma and urinary phenolic metabolites (P< 0·05). There were significantly lower glucose and insulin peaks after ingestion of the FVPD compared with control (P= 0·019 and 0·003) and a trend towards increased endothelium-dependent vasodilation following FVPD consumption (P= 0·061). Overall, FVPD consumption significantly increased plasma vitamin C and total nitrate/nitrite concentrations, with a trend towards increased endothelium-dependent vasodilation. Puréed F&V products are useful vehicles for increasing micronutrient status, plasma antioxidant capacity and in vivo NO generation, which may contribute to CVD risk reduction.

译文

流行病学研究表明,富含水果和蔬菜 (F & V) 的饮食对心血管疾病有保护作用。纯净的F & V产品保留了许多有益的成分,包括类黄酮,类胡萝卜素,维生素c和膳食纤维。本研究旨在确定急性摄入F & V浓汤饮料 (FVPD) 对血管舒张,抗氧化状态,植物化学生物利用度和其他CVD危险因素的生理影响。共有24名年龄在30-70岁之间的受试者完成了随机,单盲,对照,交叉测试餐研究。在低类黄酮饮食5天后,受试者食用了400毫升FVPD或水果味糖匹配对照。在整个研究日收集血液和尿液样本,并使用激光多普勒离子电渗疗法以90分钟的间隔评估血管反应性。FVPD显着增加血浆维生素c (P = 0·002) 和总硝酸盐/亚硝酸盐 (P = 0·001) 的浓度。离体LDL氧化的治疗效果几乎有显着的时间 (P = 0·068),消耗FVPD后的滞后阶段更长。在榨汁后6 h,血浆抗氧化能力显着增加 (P = 0·003),血浆和尿中酚类代谢产物同时增加 (P< 0·05)。与对照组相比,摄入FVPD后葡萄糖和胰岛素峰值显着降低 (P = 0·019和0·003),并且在消耗FVPD后内皮依赖性血管舒张趋势增加 (P = 0·061)。总体而言,FVPD的摄入显着增加了血浆维生素c和总硝酸盐/亚硝酸盐浓度,并有增加内皮依赖性血管舒张的趋势。纯净的F & V产品是增加微量营养素状态,血浆抗氧化能力和体内NO生成的有用载体,这可能有助于降低CVD风险。

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