Samples sizes are calculated for case-control studies where 1:1 matching has been employed, and where the goal is the interval estimation of the odds ratio. The optimal sample size is defined to be the smallest value for which a 100(1 - alpha)% confidence interval for the log odds ratio will not exceed a specified width 2 delta with specified probability (1 - gamma). This approach is similar in spirit to the power-based approach for sample size determination when significance testing is the goal. Tables of sample sizes are presented for various choices of parameters. We also find considerable disagreement with a published method based on expected numbers of discordant pairs.

译文

为案例对照研究计算样本大小,其中采用了1:1匹配,目标是比值比的区间估计。最佳样本量被定义为最小值,对数优势比的100(1-α) % 置信区间将不超过具有指定概率 (1-γ) 的指定宽度2增量。当显著性测试是目标时,这种方法在精神上类似于基于功率的方法来确定样本量。给出了各种参数选择的样本大小表。我们还发现,基于不一致对的预期数量,与已发布的方法存在很大分歧。

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