Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A-C (1-3) and eight known compounds, 5,4'-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4'-dihydroxy-7,3'-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC50 values of 0.12 ± 0.06 and 1.86 ± 0.18 (µM), respectively.

译文

对牡荆叶片甲醇提取物的植物化学研究导致隔离出三种新的labdane型二萜类化合物,牡荆内酯A-C (1-3) 和八种已知化合物,5,4 '-dihydroxy-3,7-二甲氧基黄酮 (4),vitecetin (5),5,4'-dihydroxy-7,3 '-二甲氧基黄酮 (6),verrucosin (7),2α,3α-二羟基-urs-12-en-28-oic酸 (8),白沙糖酸 (9),18,19-seco,2α,3α-二羟基-19-oxo-urs-11,13(18)-dien-28-oic (10) 和山糖油酸 (11)。通过物理和化学方法阐明了它们的化学结构。评估了所有化合物对CVB3,HRV1B和EV71病毒的抗病毒活性。结果,化合物4和6显示出针对CVB3感染的有效抗病毒活性,IC50值分别为0.12 ± 0.06和1.86 ± 0.18 (µ m)。

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