At the start of the 21st century, respiratory syncytial virus (RSV) remains a serious global health concern. Although RSV has traditionally been acknowledged as a leading cause of morbidity and mortality in the paediatric population, the elderly and people with suppressed immune systems are now also recognised as being at risk from serious RSV infection. This problem is currently exacerbated by the lack of an effective vaccine to prevent RSV infection. Although the virus proteins play a variety of roles during the virus replication cycle, in many cases these tasks are performed via specific interactions with host-cell factors, including proteins, carbohydrates and lipids. The way in which RSV interacts with the host cell is currently being examined using a battery of different techniques, which encompass several scientific disciplines. This is providing new and interesting insights into how RSV interacts with the host cell at the molecular level, which in turn is offering the hope of new strategies to prevent RSV infection.

译文

在21世纪开始时,呼吸道合胞病毒 (RSV) 仍然是一个严重的全球健康问题。尽管传统上认为RSV是儿科人群发病率和死亡率的主要原因,但老年人和免疫系统受到抑制的人现在也被认为有严重RSV感染的风险。目前,由于缺乏有效的疫苗来预防RSV感染,这一问题更加严重。尽管病毒蛋白在病毒复制周期中起着多种作用,但在许多情况下,这些任务是通过与宿主细胞因子 (包括蛋白质,碳水化合物和脂质) 的特定相互作用来执行的。RSV与宿主细胞相互作用的方式目前正在使用一系列不同的技术进行检查,该技术涵盖了多个科学学科。这为RSV如何在分子水平上与宿主细胞相互作用提供了新的有趣的见解,这反过来又为预防RSV感染的新策略提供了希望。

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