Annexin A2 is a membrane scaffolding and binding protein, which mediated various cellular events. Its functions are generally affected by cellular localization. In the cytoplasm, they interacted with different phospholipid membranes in Ca2+ -dependent manner and play vital roles including actin binding, remodeling and dynamics, cytoskeletal rearrangement, and lipid-raft microdomain formation. However, upon cell exposure to certain stimuli, annexin A2 translocates to the external leaflets of the plasma membrane where annexin A2 was recently reported to serve as a virus receptor, play an important role in the formation of virus replication complex, or implicated in virus assembly and budding. Here, we review some of annexin A2 roles in virus infections and the potentiality of targeting annexin A2 in the design of novel and promising antivirus agent that may have a broader consequence in virus therapy.

译文

膜联蛋白A2是一种膜支架和结合蛋白,介导各种细胞事件。其功能一般受细胞定位的影响。在细胞质中,它们以Ca2依赖性方式与不同的磷脂膜相互作用,并发挥重要作用,包括肌动蛋白结合,重塑和动力学,细胞骨架重排和脂质筏微区形成。然而,当细胞暴露于某些刺激时,膜联蛋白A2易位至质膜的外部小叶,最近据报道膜联蛋白A2充当病毒受体,在病毒复制复合物的形成中起重要作用,或与病毒组装和出芽有关。在这里,我们回顾了膜联蛋白A2在病毒感染中的一些作用,以及靶向膜联蛋白A2在设计新颖而有前途的抗病毒剂中的潜力,这些杀病毒可能在病毒治疗中产生更广泛的影响。

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