Gastro-oesophageal reflux disease (GORD) is associated with a broad array of symptoms that may be typical or atypical of the disease and that may be accompanied by erosive oesophagitis. Symptom scales that have historically been employed to assess response to treatment in GORD clinical trials do not typically account for the heterogeneous, episodic nature of GORD and the poor correlation between patients' and physicians' assessment of symptoms. The ReQuest questionnaire permits self-assessment of changes on a broad range of GORD-related symptoms on a daily basis and in combination with the Los Angeles (LA)-classification (ReQuest/LA-classification) to assess complete remission of GORD. Pantoprazole and esomeprazole are two of the newer proton pump inhibitors and are the first to be systematically reviewed using the ReQuest(trade mark) questionnaire. Results from recent head-to-head trials have shown pantoprazole and esomeprazole to be highly and equally effective treatments for (i) rapid and sustained relief of ReQuest-assessed GORD-related symptoms in patients with non-erosive GORD or endoscopically confirmed erosive GORD, and (ii) achieving a combined outcome comprising endoscopically confirmed healing and ReQuest-assessed symptom relief in patients with erosive GORD. There is some preliminary evidence to suggest that pantoprazole may be the better choice of treatment in terms of its potential to maintain control of symptoms in patients for whom night-time symptoms are a concern and if taken as on-demand rather than continuous maintenance therapy.

译文

胃食管反流病 (GORD) 与多种症状有关,这些症状可能是该疾病的典型或非典型症状,并可能伴有糜烂性食管炎。历史上用于评估GORD临床试验对治疗反应的症状量表通常不能解释GORD的异质性,发作性以及患者和医生对症状的评估之间的不良相关性。请求问卷允许每天对广泛的GORD相关症状的变化进行自我评估,并结合洛杉矶 (LA) 分类 (请求/LA-分类) 来评估GORD的完全缓解。泮托拉唑和埃索美拉唑是两种较新的质子泵抑制剂,并且是第一个使用请求 (商标) 问卷进行系统审查的药物。最近的头对头试验的结果表明,泮托拉唑和埃索美拉唑是高度和同等有效的治疗方法,可用于 (i) 快速和持续缓解非糜烂性GORD或经内镜证实的糜烂性GORD患者的请求评估的GORD相关症状,(ii) 在糜烂性GORD患者中实现包括经内窥镜证实的愈合和请求评估的症状缓解的综合结果。有一些初步证据表明,pan托拉唑可能是更好的治疗选择,因为pan托拉唑可以维持夜间症状受到关注的患者的症状控制,并且如果按需而不是连续维持治疗。

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