Pantoprazole is a new substituted benzimidazole, which is a potent inhibitor of gastric acid secretion by its inhibition of H+,K(+)-ATPase. Pantoprazole, 40 mg, was compared with the H2-receptor antagonist ranitidine, 300 mg, in the healing of acute duodenal ulcer. Two hundred seventy-six patients with endoscopically diagnosed duodenal ulcer were studied in this multicenter double-blind study. Patients were reendoscopied after two weeks of treatment, and those patients whose ulcers remained unhealed were also endoscoped after an additional two weeks of treatment. The primary end point was the complete healing of the ulcer. Demographic characteristics were comparable in both treatment groups. After two weeks of treatment, 90/124 (73%) patients in the pantoprazole group had healed ulcers compared with 57/126 (45%) patients in the ranitidine group (P < 0.001, per-protocol analysis). After four weeks, the cumulative healing rates were 92% and 84% in the pantoprazole and ranitidine groups, respectively (P = 0.073). Symptoms were also improved at week 2, with 84% and 72% of patients in the pantoprazole and ranitidine groups, respectively, reporting no ulcer pain (P < 0.05, per-protocol analysis). Both treatments were well tolerated. This study has confirmed the superiority of pantoprazole compared with ranitidine in the healing of duodenal ulcers and pain relief after two weeks of treatment and has shown pantoprazole to be well tolerated in this indication.

译文

泮托拉唑是一种新的取代苯并咪唑,它通过抑制H,K ()-atp酶而成为胃酸分泌的有效抑制剂。将40 mg的泮托拉唑与H2-receptor拮抗剂雷尼替丁300 mg在急性十二指肠溃疡的愈合中进行了比较。在这项多中心双盲研究中,对76例经内镜诊断为十二指肠溃疡的患者进行了研究。治疗两周后,患者进行了内窥镜检查,而那些溃疡仍未愈合的患者在另外两周的治疗后也进行了内窥镜检查。主要终点是溃疡完全愈合。两个治疗组的人口统计学特征具有可比性。治疗2周后,泮托拉唑组90/124例 (73% 例) 溃疡愈合,雷尼替丁组57/126例 (45% 例) 溃疡愈合 (P <0.001,符合方案分析)。4周后,泮托拉唑组和雷尼替丁组的累积治愈率分别为92% 和84% (P = 0.073)。在第2周时症状也得到改善,泮托拉唑组和雷尼替丁组分别有84% 和72% 患者,报告无溃疡疼痛 (P <0.05,符合方案分析)。两种治疗都具有良好的耐受性。这项研究证实了泮托拉唑与雷尼替丁相比,在治疗两周后的十二指肠溃疡愈合和缓解疼痛方面具有优势,并表明泮托拉唑在这种适应症中具有良好的耐受性。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录