Pantoprazole is a specific inhibitor of the H+/K(+)-ATPase of the gastric parietal cell. The dose-dependency of a range of pantoprazole pharmacokinetic characteristics was studied. Twelve healthy male subjects were given 10, 20, 40 and 80 mg pantoprazole intravenously according to a randomized, single blind, 4-period change-over scheme. The area under the concentration vs time curve (AUC) and the maximum serum concentration (Cmax) showed a linear increase in line with the dose. Apparent volume of distribution (Vd area), clearance (Cl) and terminal half-life (t1/2) were independent of the dose. The dose-independent elimination of pantoprazole was attributed to the lack of interaction of the drug with cytochrome P450. In clinical practice, a good predictable response, as well as a low potential for interaction with other drugs might be expected.

译文

泮托拉唑是胃壁细胞H/K ()-ATPase的特异性抑制剂。研究了一系列泮托拉唑药代动力学特征的剂量依赖性。根据随机,单盲,4期转换方案,对12名健康男性受试者进行了10、20、40和80 mg泮托拉唑的静脉注射。浓度与时间曲线下的面积 (AUC) 和最大血清浓度 (Cmax) 随剂量呈线性增加。表观分布体积 (Vd面积),清除率 (Cl) 和末端半衰期 (t1/2) 与剂量无关。pantoprazole的剂量依赖性消除归因于药物与细胞色素p450缺乏相互作用。在临床实践中,可以预期良好的可预测反应以及与其他药物相互作用的潜力较低。

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