The aim of the study was to evaluate the prevalence of hepatitis C virus (HCV) and hepatitis B virus (HBV) in district Vehari, Pakistan; and to highlight the alarming situation of HCV. This survey was conducted in the district from June to August 2018. A total of 697 (72.99%) cases out of 955, were found to be infected with hepatitis viruses, among which, 681 (71.3%) were infected with HCV and 16 (1.68%) with HBV. HCV was found more prevalent in females while more cases of HBV were reported in males. Overall age ranged from 31 to 60 years, with females from 51-60 years; infected with HCV and HBV in male with age range 19-30 years infected with HBV. The situation of the seroprevalence of HCV is alarming and the authorities in Pakistan should take extensive measures for the elimination of the hepatitis viruses from Pakistan. Key Words: Seroprevalence, Hepatitis C virus, Hepatitis B virus, Pakistan.