Introduction: Antibiotics have saved and are still saving countless human lives from the burden of infectious diseases. However, as with all other drugs, they can cause adverse events. Generally, these are uncommon, mild and spontaneously resolving. However, in some cases, they can cause relevant clinical problems. Compared with adults, children, particularly in the first years of life, have a higher risk of antibiotic-related adverse events for several reasons. Areas covered: In this paper, the conditions that can contribute to the elevated risk of antibiotic-related adverse events in children are discussed. Expert opinion: Antibiotic stewardship can be a solution to limit antibiotic abuse and misuse and consequently the incidence of antibiotic-related adverse events in children. Moreover, most of the antibiotic-associated adverse events can be avoided with more extensive pre-marketing medicine investigations, improved postmarket safety surveillance system, increased transparency throughout the clinical research enterprise, increased training of clinical pharmacologists and paediatric researchers, expanded pool of paediatric patients, and providing additional funding and incentives for paediatric drug development.

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简介: 抗生素已经挽救了,并且仍在挽救无数人的生命,摆脱传染病的负担。然而,与所有其他药物一样,它们可能导致不良事件。通常,这些是不常见的,温和的且自发解决的。但是,在某些情况下,它们可能会导致相关的临床问题。与成人相比,儿童,尤其是生命的最初几年,由于多种原因,发生抗生素相关不良事件的风险更高。涉及的领域: 本文讨论了可能导致儿童抗生素相关不良事件风险升高的条件。专家意见: 抗生素管理可以是一种解决方案,以限制抗生素的滥用和误用,从而限制儿童抗生素相关不良事件的发生率。此外,大多数抗生素相关的不良事件可以通过更广泛的上市前医学调查,改进的上市后安全监测系统,提高整个临床研究企业的透明度,增加临床药理学家和儿科研究人员的培训,扩大儿科患者库,并为儿科药物开发提供额外的资金和激励措施。

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