Osteopontin (OPN) is recognized for its significant roles in both physiological and pathological processes. Initially, OPN was recognized as a cytokine with pro-inflammatory actions. More recently, OPN has emerged as a matricellular protein of the extracellular matrix (ECM). OPN is also known to be a substrate for proteolytic cleavage by several proteases that form an integral part of the ECM. In the adult heart under physiological conditions, basal levels of OPN are expressed. Increased expression of OPN has been correlated with the progression of cardiac remodeling and fibrosis to heart failure and the severity of the condition. The intricate process by which OPN mediates its effects include the coordination of intracellular signals necessary for the differentiation of fibroblasts into myofibroblasts, promoting angiogenesis, wound healing, and tissue regeneration. In this review, we discuss the role of OPN in contributing to the development of cardiac fibrosis and its suitability as a therapeutic target.

译文

:Osteopontin(OPN)因其在生理和病理过程中的重要作用而闻名。最初,OPN被认为是具有促炎作用的细胞因子。最近,OPN已经作为细胞外基质(ECM)的基质细胞蛋白出现。还已知OPN是被形成ECM必不可少的一部分的几种蛋白酶进行蛋白水解切割的底物。在成年心脏中,在生理条件下,基本水平的OPN被表达。 OPN的表达增加与心脏重塑和纤维化发展为心力衰竭以及病情严重程度相关。 OPN介导其作用的复杂过程包括协调成纤维细胞分化为成肌纤维细胞,促进血管生成,伤口愈合和组织再生所必需的细胞内信号的协调。在这篇综述中,我们讨论了OPN在促进心脏纤维化发展中的作用及其作为治疗靶标的适用性。

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