The use of methylphenidate (MPH) in combination with antiepileptic drugs is gaining acceptance for children with epilepsy who have the symptoms of attention-deficit hyperactivity disorder (ADHD). We report two cases of an adverse effect of dyskinesia and bruxism when MPH was given to children maintained on valproic acid. These adverse effects were rapid and severe. Because of the potential for serious and persistent side effects from this combination of medications, caution is warranted in the treatment of ADHD with MPH for children taking valproic acid. Further prospective studies of the use of valproic acid and MPH in combination are required.

译文

:哌醋甲酯(MPH)与抗癫痫药联合使用正在引起患有注意力不足过动症(ADHD)症状的癫痫儿童。我们报告了两个例子,当对维持丙戊酸的儿童给予MPH时,发生了运动障碍和磨牙症的不良影响。这些不良反应是迅速而严重的。由于这种药物联合使用可能会导致严重和持续的副作用,因此在服用丙戊酸的儿童中用MPH治疗ADHD时应格外小心。还需要对丙戊酸和MPH组合使用的进一步前瞻性研究。

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