In this study, compression-coated tablets were prepared and examined by real-time swelling/erosion analysis and dissolution studies. Of the coating materials, PVP showed no swelling behavior and had no impact on theophylline release. Polyox(®) exhibited swelling behavior of an entangled polymer, which was reflected in its > 14-hour delayed-release profile. Hydroxypropyl methylcellulose (HPMC), which revealed the characteristics of a disentangled polymer, caused a 2-h delay in theophylline release. Based on preliminary texture analysis data, Polyox(®)/PVP blends were used as coating materials to manipulate the onset of drug release from the compression-coated tablets. Of the blends, at a 1:1 ratio, for example, resulted in a burst release after 10 h, which demonstrated the feasibility of preparing delayed release dosage forms by compression coating. Furthermore, it was feasible to predict the dissolution behavior of polymers from their swelling/erosion data, which were generated from texture analysis.

译文

:在这项研究中,制备了压缩包衣片剂,并通过实时溶胀/侵蚀分析和溶出度研究进行了检查。在包衣材料中,PVP没有显示溶胀行为,对茶碱的释放没有影响。 Polyox®表现出缠结聚合物的溶胀行为,这反映在其> 14小时的延迟释放曲线中。羟丙基甲基纤维素(HPMC)揭示了缠结聚合物的特性,导致茶碱释放延迟了2小时。基于初步的质地分析数据,将Polyox®/ PVP掺合物用作包衣材料,以控制药物从压制包衣片中释放的开始。在这些混合物中,例如以1:1的比例导致10小时后爆发释放,这证明了通过压制包衣制备延迟释放剂型的可行性。此外,从由结构分析产生的溶胀/侵蚀数据预测聚合物的溶解行为是可行的。

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