Moniliformin is a Fusarium mycotoxin highly prevalent in grains and grain-based products worldwide. In this study, the acute oral toxicity of moniliformin was assessed in Sprague-Dawley male rats according to OECD Guideline 423 with a single-dose exposure. Clinical observations and histopathological changes were recorded together with the excretion of moniliformin via urine and feces, utilizing a novel liquid chromatography-mass spectrometry method. According to our study, moniliformin is acutely toxic to rats with a rather narrow range of toxicity. Moniliformin can be classified into category 2 (LD(50) cut-off value 25 mg/kg b.w.), according to the Globally Harmonized System for the classification of chemicals. The clinical observations included muscular weakness, respiratory distress and heart muscle damage. Pathological findings confirmed that heart is the main target tissue of acute moniliformin toxicity. A significant proportion (about 38%) of the administered moniliformin was rapidly excreted in urine in less than 6 h. However, the toxicokinetics of the majority of the administered dose still requires clarification, as the total excretion was only close to 42%. Considering the worldwide occurrence of moniliformin together with its high acute toxicity, research into the subchronic toxicity is of vital importance to identify the possible risk in human/animal health.

译文

:Moniliformin是一种镰刀菌真菌毒素,在世界各地的谷物和谷物产品中高度流行。在这项研究中,根据OECD准则423(单剂量暴露)评估了Sprague-Dawley雄性大鼠中莫尼利福星的急性口服毒性。使用新型液相色谱-质谱法记录临床观察结果和组织病理学变化,以及通过尿液和粪便排泄莫尼西丁。根据我们的研究,莫尼利福星对大鼠具有急性毒性,毒性范围相当狭窄。根据全球化学品统一分类制度,莫尼西丁可分为2类(LD(50)临界值25 mg / kg b.w.)。临床观察包括肌肉无力,呼吸窘迫和心肌损伤。病理结果证实,心脏是急性莫尼莫丁毒性的主要靶组织。在不到6小时的时间内,很大一部分(约38%)施用的莫尼利福星会迅速从尿液中排泄出去。然而,由于总排泄仅接近42%,因此大部分给药剂量的毒物动力学仍需要澄清。考虑到莫尼可菌素在世界范围内的流行及其高度急性毒性,对亚慢性毒性的研究对于确定人类/动物健康的潜在风险至关重要。

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