Several electrophysiological studies have addressed the interaction between glutamate and dopamine within the striatum. Although the results obtained from these studies were often conflicting, more recently the characterization of new forms of synaptic plasticity in the basal ganglia provided a possible integrative explanation of the different electrophysiological data regarding the interaction between these transmitters. In this review we will try to summarize and discuss the available data concerning the possible impact of the functional role of D1 and D2 receptor activation on the modulation of the glutamatergic corticostriatal pathway. Moreover, we will also describe the function of the striatum in the integration of glutamatergic and dopaminergic inputs to produce long-term changes of synaptic efficacy (long-term depression, long-term potentiation). Finally, we will consider the implication of the interaction between dopamine and glutamate in the regulation of energetic metabolism whose failure is responsible for neuronal death.

译文

几项电生理研究已经解决了纹状体内谷氨酸和多巴胺之间的相互作用。尽管从这些研究中获得的结果通常是矛盾的,但最近在基底神经节中新形式的突触可塑性的表征为有关这些发射器之间相互作用的不同电生理数据提供了可能的综合解释。在这篇综述中,我们将尝试总结和讨论有关D1和D2受体激活的功能作用对谷氨酸能皮质皮质激素途径调节可能产生的影响的可用数据。此外,我们还将描述纹状体在谷氨酸能和多巴胺能输入的整合中的功能,以产生突触效力的长期变化(长期抑制,长期增强)。最后,我们将考虑多巴胺和谷氨酸之间相互作用对能量代谢的调节的意义,能量代谢的失败是神经元死亡的原因。

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