Two-hundred and ninety-three patients without a previous vaginal delivery were randomized to intracervical/extra-amniotic application of 0.5 mg prostaglandin E2 (PGE2) or to gel only. Of the patients who received PGE2, 18.7% were admitted before the next morning due to spontaneous abortion, bleeding or pains. No other side-effect was observed. A statistically significant dilatation of the cervical canal was found in the prostaglandin group. Thirty percent of the treated patients did not need further dilatation of the cervix 25.4% were non-responders to PGE2 and 7.7% were hyper-responders. The number of uterine perforations, pelvic inflammatory disease (PID) or retained pregnancy products were not influenced by the pretreatment with PGE2.

译文

:293例以前没有阴道分娩的患者被随机分配至0.5 mg前列腺素E2(PGE2)的脑内/羊膜外给药或仅凝胶化。在接受PGE2的患者中,由于自然流产,出血或疼痛,第二天早上入院的患者为18.7%。没有观察到其他副作用。在前列腺素组中发现了颈管的统计学上显着的扩张。接受治疗的患者中有30%不需要进一步扩张子宫颈,PGE2无反应者为25.4%,高反应者为7.7%。子宫穿孔,盆腔炎(PID)或保留的妊娠产物的数量不受PGE2预处理的影响。

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