PURPOSE:To measure the dimensions of aqueous outflow structures and to investigate associations with intraocular pressure (IOP) and ocular biometry parameters in an older British population. METHOD:Fifty-two participants from the European Prospective Investigation of Cancer-Norfolk eye study underwent imaging using the Heidelberg Spectralis optical coherence tomographer with an anterior segment module. Pseudophakic participants and those known or suspected to have glaucoma were excluded, leaving 46 participants for analysis. Schwalbe's line (SL), scleral spur (SS), Schlemm's canal (SC) diameter and the trabecular meshwork cross-sectional area (TM cross-sectional area (CSA)) were identified and traced using ImageJ software. IOP was measured using the Ocular Response Analyser. Ocular biometry was measured by partial coherence interferometry. RESULTS:The mean (SD) subject age was 65.7 years (5.6). The SL and SS were identifiable in all nasal and temporal scans. The mean SL-SS distance was 800 μm (104) nasally and 808 μm (102) temporally. Repeatability of SS-SL, SS-SC, SC and TM CSA was good to excellent, and reproducibility fair to good. Nasal SL-SS distance was inversely associated with anterior chamber depth (ACD) (p=0.007, -116 μm per mm ACD, R(2)=0.18). Multiple linear regression showed nasal TM CSA was significantly associated with age and IOP (age: p=0.025, 0.007 mm(2) per decade of age; IOP: p=0.029, -0.0012 mm(2) per mm Hg, R(2)=0.23). CONCLUSIONS:Aqueous outflow structures can be measured by optical coherence tomography, and their dimensions vary significantly with ocular biometric characteristics and IOP. Further investigation is required to determine associations between outflow structure sizes in different populations and pathologies, including ocular hypertension and glaucoma.

译文

目的:测量年龄较大的英国人群的房水流出结构的尺寸,并调查其与眼内压(IOP)和眼生物测定参数的关系。
方法:来自欧洲-诺福克癌症前瞻性研究的52名参与者使用了带有前段模块的Heidelberg Spectralis光学相干断层扫描仪进行了成像。假晶状体参与者以及已知或怀疑患有青光眼的参与者被排除在外,剩下46名参与者需要进行分析。使用ImageJ软件识别并追踪Schwalbe线(SL),巩膜骨刺(SS),Schlemm根管(SC)直径和小梁网截面积(TM截面积(CSA))。使用眼响应分析仪测量IOP。眼部生物测定法是通过部分相干干涉法测量的。
结果:受试者的平均年龄为65.7岁(5.6)。在所有鼻腔和颞叶扫描中都可以识别出SL和SS。 SL-SS的平均距离鼻侧为800μm(104),颞侧为808μm(102)。 SS-SL,SS-SC,SC和TM CSA的可重复性从优到优,而重现性则从优到优。鼻SL-SS距离与前房深度(ACD)成反比(p = 0.007,-116μm/ mm ACD,R(2)= 0.18)。多元线性回归分析显示,鼻腔TM CSA与年龄和眼压显着相关(年龄:p = 0.025,每十岁年龄组0.007 mm(2); IOP:p = 0.029,-0.0012 mm(2)每毫米汞柱,R(2) )= 0.23)。
结论:水流出结构可以通过光学相干断层扫描来测量,其尺寸随眼生物特征和眼压的变化而显着变化。需要进一步调查以确定不同人群和病理(包括高眼压和青光眼)的流出结构大小之间的关联。

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