Purpose: Using a new analysis program for scanning laser-Doppler flowmetry (SLDF) by a Heidelberg retina flowmeter (HRF), we studied the relation between flow and visual field or disc morphology.Subjects and Methods: In 42 eyes of 21 patients with normal tension glaucoma (NTG) the mean-flow of the HRF blood flow parameters at the disc rim was measured and analyzed by a new analysis program for perfusion maps (the SLDF analysis tool), to minimize the influence of large vessels or/and artifacts caused by small eye movements. We investigated whether difference of the mean-flow between a pair of eyes had any relation to differences between a pair of eyes in visual field indices and those in disc morphological measurements of the Heidelberg retina tomograph.Results: We found statistically significant correlations between the mean-flow and optic disc parameters (Disk Area, Cup Area, Height Variation Contour, Cup Volume, Rim Volume, Mean RNFL Thickness). We found no statistically significant correlations between the mean-flow and visual field parameters (mean deviation, corrected pattern standard deviation).Conclusion: The results suggested that eyes with less flow in the optic disc rim have more advanced glaucomatous morphological changes.

译文

目的:使用海德堡视网膜流量计(HRF)的新型分析程序扫描激光多普勒血流仪(SLDF),研究血流与视野或椎间盘形态之间的关系。对象与方法:在21例患有眼疾的患者的42眼中正常张力性青光眼(NTG)通过新的灌注图分析程序(SLDF分析工具)测量并分析了椎间盘边缘HRF血流参数的平均流量,以最大程度地减少大血管或/和伪影的影响眼睛的小动作引起的。我们调查了两只眼睛的平均流量差异与两只眼睛在视野指数和海德堡视网膜断层扫描仪的椎间盘形态测量中的差异是否有任何关系。结果:我们发现平均值之间存在统计学上的显着相关性流量和光盘参数(磁盘面积,杯面积,高度变化轮廓,杯体积,轮辋体积,平均RNFL厚度)。我们发现,平均流量与视野参数(均值偏差,校正后的模式标准偏差)之间无统计学意义的相关性。结论:结果表明,视盘边缘流动较少的眼睛的青光眼形态学改变更为明显。

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