Recent studies in psychoneuroimmunology have indicated that proinflammatory cytokines cause several diseases and behaviors that overlap symptomatically with depression. It is known that the endogenous opioid peptide beta-endorphin regulates proinflammatory cytokine secretion from peripheral immune cells via mu-opioid receptor-dependent mechanisms. Therefore, it is possible that the functional polymorphism of the mu-opioid receptor gene (OPRM1, SNP: A118G) influences peripheral circulating proinflammatory cytokine levels and the health-related quality of life (QOL) even in healthy populations. In this study, we compared the serum concentrations of several proinflammatory cytokines (interleukin-2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma)) and the health-related QOL between OPRM1 genotypes. Interestingly, serum concentrations of IL-6, TNF-alpha, and IFN-gamma were significantly lower and the general health score was significantly higher in carriers of the G allele, who show a strong binding of beta-endorphin to the mu-opioid receptor as compared to individuals without the G allele. Correlation analysis indicated that the general health score was negatively correlated with the IL-6 serum concentration. These results suggest that the sensitive endogenous opioid system in carriers of the G allele may suppress proinflammatory cytokine secretion from peripheral immune cells; consequently, it may influence the health perception.

译文

心理神经免疫学的最新研究表明,促炎性细胞因子会导致多种疾病和行为,与抑郁症在症状上重叠。已知内源性阿片肽β-内啡肽通过μ阿片受体依赖性机制调节周围免疫细胞的促炎细胞因子分泌。因此,即使在健康人群中,μ阿片受体基因(OPRM1,SNP:A118G)的功能多态性也可能影响外周循环促炎细胞因子水平和健康相关的生活质量(QOL)。在这项研究中,我们比较了几种促炎细胞因子(白介素2(IL-2),白介素6(IL-6),肿瘤坏死因子α(TNF-alpha)和干扰素-γ(IFN-α)的血清浓度。 γ)和OPRM1基因型之间与健康相关的QOL。有趣的是,G等位基因携带者的血清IL-6,TNF-α和IFN-γ浓度显着降低,而总体健康评分显着更高,这些携带者表现出β-内啡肽与μ阿片受体的强烈结合与没有G等位基因的个体相比。相关分析表明,总体健康评分与IL-6血清浓度呈负相关。这些结果表明,G等位基因携带者中敏感的内源性阿片样物质系统可能抑制外周免疫细胞的促炎细胞因子分泌。因此,它可能会影响健康感知。

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