The role of the delta-opioid receptor (OPRD1) in methamphetamine (MAP) addiction was investigated using association analysis between OPRD1 gene polymorphisms and MAP dependence/psychosis. DNA samples from Japanese patients with MAP dependence/psychosis were analyzed to find polymorphisms in OPRD1 gene exons and exon-intron boundaries. One novel single nucleotide polymorphism (SNP) in intron 1 and two SNPs in exon 3 were identified. The two SNPs in exon 3 were in linkage disequilibrium. No significant difference was observed in either genotypic or allelic frequencies of these SNPs between controls (n = 260) and MAP dependent/psychotic patients (n = 170). Global analyses using the three SNPs and subcategory analyses on clinical parameters also showed no significant differences. These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis.

译文

:使用OPRD1基因多态性与MAP依赖/精神病之间的关联分析,研究了δ阿片受体(OPRD1)在甲基苯丙胺(MAP)成瘾中的作用。分析了来自日本MAP依赖/精神病患者的DNA样本,以发现OPRD1基因外显子和外显子-内含子边界的多态性。内含子1和外显子3中的两个SNPs鉴定出一种新颖的单核苷酸多态性(SNP)。外显子3中的两个SNP处于连锁不平衡状态。在对照组(n = 260)和MAP依赖/精神病患者(n = 170)之间,这些SNP的基因型或等位基因频率均未观察到显着差异。使用这三个SNP进行的全局分析以及对临床参数的子类别分析也显示无显着差异。这些结果表明,OPRD1基因变异可能不是导致MAP依赖/精神病易感性的因素。

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