Mice with cytotoxic lesions of the dorsal hippocampus (DH) underestimated 15 s and 45 s target durations in a bi-peak procedure as evidenced by proportional leftward shifts of the peak functions that emerged during training as a result of decreases in both 'start' and 'stop' times. In contrast, mice with lesions of the ventral hippocampus (VH) displayed rightward shifts that were immediately present and were largely limited to increases in the 'stop' time for the 45 s target duration. Moreover, the effects of the DH lesions were congruent with the scalar property of interval timing in that the 15 s and 45 s functions superimposed when plotted on a relative timescale, whereas the effects of the VH lesions violated the scalar property. Mice with DH lesions also showed enhanced reversal learning in comparison to control and VH lesioned mice. These results are compared with the timing distortions observed in mice lacking δ-opioid receptors (Oprd1(-/-)) which were similar to mice with DH lesions. Taken together, these results suggest a balance between hippocampal-striatal interactions for interval timing and demonstrate possible functional dissociations along the septotemporal axis of the hippocampus in terms of motivation, timed response thresholds and encoding in temporal memory.

译文

:双峰过程中具有背海马(DH)细胞毒性损伤的小鼠低估了15 s和45 s的目标持续时间,这是由训练过程中由于两个“开始”次数减少导致的峰值功能按比例向左移动所证明的和“停止”时间。相反,具有腹侧海马(VH)损伤的小鼠表现出立即向右移动,并且在45 s目标持续时间内很大程度上受限于“停止”时间的增加。此外,DH病灶的影响与间隔时间的标量特性是一致的,因为在相对时间尺度上绘制时,15 s和45 s函数是重叠的,而VH病灶的影响却违反了标量特性。与对照组和VH损伤小鼠相比,具有DH损伤的小鼠还显示出增强的逆向学习能力。将这些结果与缺少δ阿片受体(Oprd1(-/-))的小鼠中观察到的时间畸变进行了比较,这些小鼠与DH损伤的小鼠相似。两者合计,这些结果表明间隔时间的海马-纹状体相互作用之间的平衡,并证明了在动机,定时反应阈值和时间记忆编码方面沿着海马间隔时轴的可能功能分离。

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