Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid (n-3 PUFAs), is an essential polyunsaturated fatty acid in the central nervous system, and possesses many physiological functions in neurodegenerative diseases. Previously, there are some reports that n-3 PUFAs contribute to pain relief. As the antinociceptive effect of DHA alone has not been reported, this study examined the antinociceptive effect of DHA on various pain stimuli. To evaluate the antinociceptive effect of DHA on thermal and chemical nociception, we employed the tail flick test, acetic acid writhing test and formalin test in mice. DHA was orally administrated at 5, 15 and 25 mmol/kg at 30 min before measurement. DHA administration dose-dependently exerted an antinociceptive effect against thermal and chemical stimulation in comparison to the control olive oil administration. These effects of DHA were abolished when mice were pretreated with naloxone, an opioid receptor antagonist. These findings suggest that DHA has opiod receptor-mediated pain control activities, and may provide valuable information towards an advanced therapeutic approach for pain control.

译文

二十二碳六烯酸 (DHA) 是一种 ω-3多不饱和脂肪酸 (n-3 PUFAs),是中枢神经系统中必需的多不饱和脂肪酸,在神经退行性疾病中具有许多生理功能。以前,有一些报道称n-3 PUFAs有助于缓解疼痛。由于尚未报道单独使用DHA的抗伤害感受作用,因此本研究检查了DHA对各种疼痛刺激的抗伤害感受作用。为了评估DHA对热和化学伤害感受的抗伤害作用,我们在小鼠中进行了甩尾试验,乙酸扭体试验和福尔马林试验。DHA在测量前30分钟以5、15和25 mmol/kg口服给药。与对照橄榄油相比,DHA给药对热和化学刺激具有剂量依赖性的抗伤害作用。当用阿片受体拮抗剂纳洛酮预处理小鼠时,DHA的这些作用被消除了。这些发现表明DHA具有阿片受体介导的疼痛控制活性,并可能为疼痛控制的先进治疗方法提供有价值的信息。

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